α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve

α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve

Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves has specific characteristics and responds differently to alleviating drugs at cephalic versus extracephalic level. This is especially true for tricyclic antidepressants currently used for alleviating neuropa...

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Bibliographic Details
Main Authors: Saïd M’Dahoma, Matthieu Poitevin, Eric Dabala, Hugo Payan, Cecilia Gabriel, Elisabeth Mocaër, Sylvie Bourgoin, Michel Hamon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
chronic constriction injury
sciatic nerve
infraorbital nerve
neuropathic rats
mechanical allodynia
agomelatine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00587/full

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