PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism

PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism

Background The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME by a cl...

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Bibliographic Details
Main Authors:	Xi Zhang, Yi Wang, Jian Ding, Lan Xu, Pu Sun, Rong-Jing Wang, Qing-Yang Ma, Hui-Ping Liao, Hai-Long Wang, Lan-Dian Hu, Xiangyin Kong, Ling-Hua Meng
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2021-08-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/9/8/e003093.full

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