Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

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Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process. In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find tha...

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Bibliographic Details
Main Authors: Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M. van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S. Sinsimer, Elisabeth A. Gavis, Christian Behrends, Catherine Rabouille
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
Drosophila S2 cells
stress granules
Sec16
Rasputin
amino acid starvation
arsenite
elF2 alpha
phosphorylation
stress response
protein translation
protein stabilization
protein transport in the secretory pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308562
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