Indomethacin Treatment of Mice with Premalignant Oral Lesions Sustains Cytokine Production and Slows Progression to Cancer

Indomethacin Treatment of Mice with Premalignant Oral Lesions Sustains Cytokine Production and Slows Progression to Cancer

Current treatment options for head and neck squamous cell carcinoma (HNSCC) patients are often ineffective due to tumor localized and systemic immunosuppression. Using the 4-NQO mouse model of oral carcinogenesis, this study showed that premalignant oral lesion cells produce higher levels of the im...

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Bibliographic Details
Main Authors: Sara D. Johnson, M. Rita I. Young
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Cytokines
T cell
head and neck cancer
immune
HNSCC
Premalignant oral lesions
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00379/full

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