Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain

Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain

Oxidative stress and insulin resistance play major roles in numerous neurodegenerative diseases, including Alzheimer’s disease (AD). A high-fat diet induces obesity-associated oxidative stress, neuronal insulin resistance, microglial activation, and neuroinflammation, which are considered...

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Bibliographic Details
Main Authors: Jong Ryeal Hahm, Myeung Hoon Jo, Rahat Ullah, Min Woo Kim, Myeong Ok Kim
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
obesity
oxidative stress
neuroinflammation
insulin resistance
amyloid-beta
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/9/1/249

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