Efficient Synthesis of Novel Pyridine-Based Derivatives via Suzuki Cross-Coupling Reaction of Commercially Available 5-Bromo-2-methylpyridin-3-amine: Quantum Mechanical Investigations and Biological Activities

The present study describes palladium-catalyzed one pot Suzuki cross-coupling reaction to synthesize a series of novel pyridine derivatives 2a–2i, 4a–4i. In brief, Suzuki cross-coupling reaction of 5-bromo-2-methylpyridin-3-amine (1) directly or via N-[5-bromo-2-methylpyridine-3-yl]acetamide (3) wit...

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Bibliographic Details
Main Authors: Gulraiz Ahmad, Nasir Rasool, Hafiz Mansoor Ikram, Samreen Gul Khan, Tariq Mahmood, Khurshid Ayub, Muhammad Zubair, Eman Al-Zahrani, Usman Ali Rana, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/22/2/190