Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation.

Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation.

RAS mutations are frequently found among acute myeloid leukemia patients (AML), generating a constitutively active signaling protein changing cellular proliferation, differentiation and apoptosis. We have previously shown that treatment of AML patients with high-dose cytarabine is preferentially ben...

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Bibliographic Details
Main Authors: Cornelia Brendel, Sabine Teichler, Axel Millahn, Thorsten Stiewe, Michael Krause, Kathleen Stabla, Petra Ross, Minh Huynh, Thomas Illmer, Marco Mernberger, Christina Barckhausen, Andreas Neubauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4406710?pdf=render

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