Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN

Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN

Flaviviruses implement a broad range of antagonism strategies against the host antiviral response. A pivotal component of the early host response is production and signaling of type I interferon (IFN-I). Ubiquitin, a prevalent cellular protein-modifying molecule, is heavily involved in the cellular...

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Main Authors: Erika Hay-McCullough, Juliet Morrison
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
interferon
flavivirus
ubiquitin
interferon antagonism
Online Access:https://www.mdpi.com/1999-4915/13/5/763
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spelling doaj-ca3be0219cea4487a98749753445a78a2021-04-27T23:00:26ZengMDPI AGViruses1999-49152021-04-011376376310.3390/v13050763Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFNErika Hay-McCullough0Juliet Morrison1Department of Microbiology and Plant Pathology, University of California, Riverside, CA 92521, USADepartment of Microbiology and Plant Pathology, University of California, Riverside, CA 92521, USAFlaviviruses implement a broad range of antagonism strategies against the host antiviral response. A pivotal component of the early host response is production and signaling of type I interferon (IFN-I). Ubiquitin, a prevalent cellular protein-modifying molecule, is heavily involved in the cellular regulation of this and other immune response pathways. Viruses use ubiquitin and ubiquitin machinery to antagonize various steps of these pathways through diverse mechanisms. Here, we highlight ways in which flaviviruses use or inhibit ubiquitin to antagonize the antiviral IFN-I response.https://www.mdpi.com/1999-4915/13/5/763interferonflavivirusubiquitininterferon antagonism
collection DOAJ
language English
format Article
sources DOAJ
author Erika Hay-McCullough
Juliet Morrison
spellingShingle Erika Hay-McCullough
Juliet Morrison
Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
Viruses
interferon
flavivirus
ubiquitin
interferon antagonism
author_facet Erika Hay-McCullough
Juliet Morrison
author_sort Erika Hay-McCullough
title Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
title_short Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
title_full Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
title_fullStr Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
title_full_unstemmed Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
title_sort contributions of ubiquitin and ubiquitination to flaviviral antagonism of type i ifn
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2021-04-01
description Flaviviruses implement a broad range of antagonism strategies against the host antiviral response. A pivotal component of the early host response is production and signaling of type I interferon (IFN-I). Ubiquitin, a prevalent cellular protein-modifying molecule, is heavily involved in the cellular regulation of this and other immune response pathways. Viruses use ubiquitin and ubiquitin machinery to antagonize various steps of these pathways through diverse mechanisms. Here, we highlight ways in which flaviviruses use or inhibit ubiquitin to antagonize the antiviral IFN-I response.
topic interferon
flavivirus
ubiquitin
interferon antagonism
url https://www.mdpi.com/1999-4915/13/5/763
work_keys_str_mv AT erikahaymccullough contributionsofubiquitinandubiquitinationtoflaviviralantagonismoftypeiifn
AT julietmorrison contributionsofubiquitinandubiquitinationtoflaviviralantagonismoftypeiifn
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