Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis

• Main Authors: Semi Hwang, Jung-eun Lim, Yoonjeong Choi, Sun Ha Jee
• Format: Article
• Language: English
• Published: BMC 2018-11-01
• Series: BMC Endocrine Disorders
• Subjects: Bisphenol a (BPA); Endocrine disrupting chemicals (EDCs); Diabetes mellitus (DM); Type 2 diabetes mellitus (T2DM); Hemoglobin A1c (HbA1c); Fasting plasma glucose
• Online Access: http://link.springer.com/article/10.1186/s12902-018-0310-y

Abstract Background This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations. Methods The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models. Results A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31). Conclusions This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans.