Residue-by-residue analysis of cotranslational membrane protein integration in vivo

Residue-by-residue analysis of cotranslational membrane protein integration in vivo

We follow the cotranslational biosynthesis of three multispanning Escherichia coli inner membrane proteins in vivo using high-resolution force profile analysis. The force profiles show that the nascent chain is subjected to rapidly varying pulling forces during translation and reveal unexpected comp...

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Bibliographic Details
Main Authors: Felix Nicolaus, Ane Metola, Daphne Mermans, Amanda Liljenström, Ajda Krč, Salmo Mohammed Abdullahi, Matthew Zimmer, Thomas F Miller III, Gunnar von Heijne
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
membrane protein
cotranslational
biogenesis
EmrE
GlpG
BtuC
Online Access:https://elifesciences.org/articles/64302

Internet

https://elifesciences.org/articles/64302

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