ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression

ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression

The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers. However, the post-translational modification of CLDN3 and its biological function remains poorly u...

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Bibliographic Details
Main Authors: Meng Yuan, Xiaobing Chen, Yitang Sun, Li Jiang, Zhongni Xia, Kaixiong Ye, Hong Jiang, Bo Yang, Meidan Ying, Ji Cao, Qiaojun He
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Claudin-3
ZDHHC12
S-Palmitoylation
Ovarian cancer
Cancer progression
Membrane localization
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520305451

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