Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FO...

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Bibliographic Details
Main Authors: Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, Jihye Paik
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20839-0

Internet

https://doi.org/10.1038/s41467-020-20839-0

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