Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines

CD133 is a cellular surface protein, which has been reported to be a cancer stem cell marker, and thus is considered a potential target for cancer treatment. Metformin, one of the biguanides used for the treatment of diabetes, is also known to reduce the risk of cancer development and cancer stem-li...

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Bibliographic Details
Main Authors: Osamu Maehara, Shunsuke Ohnishi, Ayaka Asano, Goki Suda, Mitsuteru Natsuizaka, Koji Nakagawa, Masanobu Kobayashi, Naoya Sakamoto, Hiroshi Takeda
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619300624