Effect of Maternal Body Mass Index on Serum Magnesium Level in Pregnant Women with Preeclampsia at Maharat Nakhon Ratchasima Hospital

• Main Authors: Pemika Jaisamut, Siraya Kitiyodom
• Format: Article
• Language: English
• Published: The Royal Thai College of Obstetricians and Gynaecologists 2017-09-01
• Series: Thai Journal of Obstetrics and Gynaecology
• Subjects: severe preeclampsia; maternal body mass index (BMI); overweight; serum magnesium level.
• Online Access: https://tci-thaijo.org/index.php/tjog/article/download/63874/82939/
• ISSN: 0857-6084; 0857-6084

Objectives: To compare serum magnesium level in pregnant women with severe preeclampsia between normal body mass index (BMI) and high BMI after receiving magnesium sulfate at Maharat Nakhon Ratchasima Hospital. Materials and Methods: The prospective study of 52 pregnant women with severe preeclampsia who received magnesium sulfate for preventing seizure at Maharat Nakhon Ratchasima Hospital during May 2015 to November 2015. The patients were pregnant women with severe preeclampsia who were given 4 grams and then a 1 gram per hour as a maintenance dose. Serum magnesium level was monitored every 4 hours during magnesium sulfate infusion and level was considered subtherapeutic if it was less than 4.8 mg/dL, therapeutic from 4.8 – 8.4 mg/dL and supratherapeutic at 8.5 mg/dL or more. The magnesium sulfate infusion was adjusted after delivery to maintain therapeutic serum magnesium level. The first serum magnesium level and the first one after delivery were collected to compare between two groups of patients divided by the body mass index (BMI): normal BMI (BMI < 25 kg/m2), and high BMI (BMI ≥ 25 kg/m2).Results: A total of 119 patients were diagnosed with severe preeclampsia during the period of study. There were 52 women who met the inclusion criteria. Normal BMI group was proved to have a higher chance of therapeutic serum magnesium level by both records significantly (RR 10.0, 95%CI 1.38-72.61 and 4.33, 95%CI 1.39 – 13.44) (P = 0.005, 0.0027 respectively). After delivery, the high BMI group tends to have higher dose of magnesium sulfate infusion to maintain therapeutic serum magnesium level.Conclusion: Body weight of the pregnant woman has effected serum magnesium level. The BMI of more than 25 kg/m2 tends to get subtherapeutic serum magnesium level. However the study has been found no seizure in patients with subtherapeutic serum magnesium level in both groups. No case of supratherapeutic serum magnesium level was found during magnesium sulfate infusion 1 gram per hour.