Effects of Tripterygium wilfordii combined with viaminate capsules on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB

• Main Authors: Ting Liu, Yun-Zhu Mou, Yan Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-09-01
• Series: Journal of Hainan Medical University
• Subjects: Tripterygium wilfordii; Viaminate capsules; Psoriasis; Immune; Endothelium; Inflammatory reaction; SICAM-1; NF-Kb
• Online Access: http://www.hnykdxxb.com/PDF/201817/19.pdf

Objective: To explore the effects of Tripterygium wilfordii combined with viaminate on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB. Methods: A total of 112 patients with psoriasis admitted in our hospital from September 2015 to November 2017 were randomly divided into control group (n=56) and observation group (n=56). The control group was treated only by Viaminate Capsules, and the observation group was treated with Tripterygium wilfordii tablet on the basis of the control group, the immune function, endothelial, inflammatory response, soluble intercellular adhesion molecules-1 (sICAM-1) and nuclear transcription factor-kB (NF-kB) expression levels were compared before and after treatment in the two groups. Results: Before treatment, CD4+, CD8+, CD4+/ CD8+, vascular endothelial growth factor (VEGF), nitric oxide (NO), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), NF-kB, and sICAM-1 in two groups were no significant difference. After treatment, CD4+ and CD4+/CD8+ in both groups were significantly increased, while CD8+ was significantly lower than before treatment, the CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group, and CD8+ was obviously lower than that of the control group; The VEGF, NO and ET-1 in both groups were dramatically lower than those before treatment, and the VEGF, NO and ET-1 in the observation group were significantly lower than those in the control group; The TNF-α and IFN-γ in two groups were significantly lower than before treatment, and TNF-α and IFN-γ in the observation group were remarkably lower than those in the control group; The NF-kB and sICAM-1 in two groups were obviously decreased than those before treatment, and the NF-kB and sICAM-1 in the observation group were significantly lower than those in the control group. Conclusion: Tripterygium wilfordii combined with viaminate capsules in the treatment of psoriasis patients, can effectively correct their immune dysfunction, improve endothelial function, reduce inflammatory response and inhibit the expression of NFkB and sICAM-1 expression.