Low Copper and High Manganese Levels in Prion Protein Plaques

Low Copper and High Manganese Levels in Prion Protein Plaques

Accumulation of aggregates rich in an abnormally folded form of the prion protein characterize the neurodegeneration caused by transmissible spongiform encephalopathies (TSEs). The molecular triggers of plaque formation and neurodegeneration remain unknown, but analyses of TSE-infected brain homogen...

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Bibliographic Details
Main Authors: Debbie McKenzie, Judd M. Aiken, Christopher J. Johnson, P.U.P.A. Gilbert, Mike Abrecht, Katherine L. Baldwin, Robin E. Russell, Joel A. Pedersen
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Viruses
Subjects:
transmissible spongiform encephalopathy
X-ray photoemission
copper
manganese
prion
brain
Online Access:http://www.mdpi.com/1999-4915/5/2/654

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