LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemically active metabolically stable apelin-17 analog, p...

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Bibliographic Details
Main Authors: Adrien Flahault, Mathilde Keck, Pierre-Emmanuel Girault-Sotias, Lucie Esteoulle, Nadia De Mota, Dominique Bonnet, Catherine Llorens-Cortes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
apelin
metabolically stable apelin analogs
APJ receptor
hypertension
DOCA-salt hypertensive rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.715095/full

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