NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Abstract Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid beta (Aβ) toxicity. Pharmacological block of NMDAR subu...

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Bibliographic Details
Main Authors: Michaela Kerstin Müller, Eric Jacobi, Kenji Sakimura, Roberto Malinow, Jakob von Engelhardt
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Acta Neuropathologica Communications
Subjects:
NMDA receptor
Amyloid Beta
Alzheimer’s disease
GluN2B
GluN2A
Online Access:http://link.springer.com/article/10.1186/s40478-018-0611-4

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