Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy.

Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy.

HIV-1 DNA in blood monocytes is considered a viral source of various HIV-1 infected tissue macrophages, which is also known as "Trojan horse" hypothesis. However, whether these DNA can produce virions has been an open question for years, due to the inability of isolating high titer and inf...

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Main Authors: Tong Wang, Younong Xu, Haiying Zhu, Thomas Andrus, Sergei B Ivanov, Charlotte Pan, Jazel Dolores, Gregory C Dann, Michael Zhou, Dominic Forte, Zihuan Yang, Sarah Holte, Lawrence Corey, Tuofu Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669022?pdf=render

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