(1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate

(1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate

The title compound, C17H24NO5S+·C18H13O8−, is the key intermediate during the preparation of lesatropane [systematic name (1R,3S,5R,6S)-6-acetoxy-3-(4-methylphenylsulfonyloxy)tropane], a potential antiglaucoma agent. The tertiary N atom of the tropane ring is involved in i...

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Main Authors: Yang Lu, Hong-Zhuan Chen, Ya-Fang Gu, Yi-Fan Xie, Li-Min Yang
Format: Article
Language:English
Published: International Union of Crystallography 2009-05-01
Series:Acta Crystallographica Section E
Online Access:http://scripts.iucr.org/cgi-bin/paper?S1600536809012732
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spelling doaj-ca0fa8ace738460b83a0f63b4be44de42020-11-25T01:22:57ZengInternational Union of CrystallographyActa Crystallographica Section E1600-53682009-05-01655o1037o103710.1107/S1600536809012732(1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoateYang LuHong-Zhuan ChenYa-Fang GuYi-Fan XieLi-Min YangThe title compound, C17H24NO5S+·C18H13O8−, is the key intermediate during the preparation of lesatropane [systematic name (1R,3S,5R,6S)-6-acetoxy-3-(4-methylphenylsulfonyloxy)tropane], a potential antiglaucoma agent. The tertiary N atom of the tropane ring is involved in intermolecular N—H...O hydrogen bonding, and the carboxylate groups are involved in intermolecular O—H...O hydrogen bonding. http://scripts.iucr.org/cgi-bin/paper?S1600536809012732
collection DOAJ
language English
format Article
sources DOAJ
author Yang Lu
Hong-Zhuan Chen
Ya-Fang Gu
Yi-Fan Xie
Li-Min Yang
spellingShingle Yang Lu
Hong-Zhuan Chen
Ya-Fang Gu
Yi-Fan Xie
Li-Min Yang
(1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
Acta Crystallographica Section E
author_facet Yang Lu
Hong-Zhuan Chen
Ya-Fang Gu
Yi-Fan Xie
Li-Min Yang
author_sort Yang Lu
title (1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
title_short (1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
title_full (1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
title_fullStr (1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
title_full_unstemmed (1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate
title_sort (1r,3s,5r,6s)-6-acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2r,3r)-2,3-bis(benzoyloxy)-3-carboxypropanoate
publisher International Union of Crystallography
series Acta Crystallographica Section E
issn 1600-5368
publishDate 2009-05-01
description The title compound, C17H24NO5S+·C18H13O8−, is the key intermediate during the preparation of lesatropane [systematic name (1R,3S,5R,6S)-6-acetoxy-3-(4-methylphenylsulfonyloxy)tropane], a potential antiglaucoma agent. The tertiary N atom of the tropane ring is involved in intermolecular N—H...O hydrogen bonding, and the carboxylate groups are involved in intermolecular O—H...O hydrogen bonding.
url http://scripts.iucr.org/cgi-bin/paper?S1600536809012732
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AT hongzhuanchen 1r3s5r6s6acetoxy8methyl3ptolylsulfonyloxy8azoniabicyclo321octane2r3r23bisbenzoyloxy3carboxypropanoate
AT yafanggu 1r3s5r6s6acetoxy8methyl3ptolylsulfonyloxy8azoniabicyclo321octane2r3r23bisbenzoyloxy3carboxypropanoate
AT yifanxie 1r3s5r6s6acetoxy8methyl3ptolylsulfonyloxy8azoniabicyclo321octane2r3r23bisbenzoyloxy3carboxypropanoate
AT liminyang 1r3s5r6s6acetoxy8methyl3ptolylsulfonyloxy8azoniabicyclo321octane2r3r23bisbenzoyloxy3carboxypropanoate
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