‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects

‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in biological chemistry and biomedicine. CORMs kill bacteria in culture and in animal models, but are reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru...

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Bibliographic Details
Main Authors: Hannah M. Southam, Michael P. Williamson, Jonathan A. Chapman, Rhiannon L. Lyon, Clare R. Trevitt, Peter J. F. Henderson, Robert K. Poole
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
amino acid
antimicrobial agent
bacteria
carbon monoxide
CORM-2
glutathione
Online Access:https://www.mdpi.com/2076-3921/10/6/915

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