Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contri...

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Main Authors: J. Rivera-Correa, J. J. Guthmiller, R. Vijay, C. Fernandez-Arias, M. A. Pardo-Ruge, S. Gonzalez, N. S. Butler, A. Rodriguez
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01476-6
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spelling doaj-ca046ba7684d4a96b9538349ba8e75232021-05-11T07:47:31ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-01476-6Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malariaJ. Rivera-Correa0J. J. Guthmiller1R. Vijay2C. Fernandez-Arias3M. A. Pardo-Ruge4S. Gonzalez5N. S. Butler6A. Rodriguez7Department of Microbiology, New York University School of MedicineDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences CenterDepartment of Microbiology and Immunology, University of IowaDepartment of Microbiology, New York University School of MedicineDepartment of Microbiology, New York University School of MedicineDepartment of Microbiology, New York University School of MedicineDepartment of Microbiology and Immunology, University of IowaDepartment of Microbiology, New York University School of MedicineAutoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contribute to anaemia onset.https://doi.org/10.1038/s41467-017-01476-6
collection DOAJ
language English
format Article
sources DOAJ
author J. Rivera-Correa
J. J. Guthmiller
R. Vijay
C. Fernandez-Arias
M. A. Pardo-Ruge
S. Gonzalez
N. S. Butler
A. Rodriguez
spellingShingle J. Rivera-Correa
J. J. Guthmiller
R. Vijay
C. Fernandez-Arias
M. A. Pardo-Ruge
S. Gonzalez
N. S. Butler
A. Rodriguez
Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
Nature Communications
author_facet J. Rivera-Correa
J. J. Guthmiller
R. Vijay
C. Fernandez-Arias
M. A. Pardo-Ruge
S. Gonzalez
N. S. Butler
A. Rodriguez
author_sort J. Rivera-Correa
title Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_short Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_full Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_fullStr Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_full_unstemmed Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_sort plasmodium dna-mediated tlr9 activation of t-bet+ b cells contributes to autoimmune anaemia during malaria
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contribute to anaemia onset.
url https://doi.org/10.1038/s41467-017-01476-6
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