Activity of the heat shock protein 90 inhibitor ganetespib in melanoma.

Activity of the heat shock protein 90 inhibitor ganetespib in melanoma.

Heat shock protein 90 (HSP90) is involved in the regulation of diverse biological processes such as cell signaling, proliferation and survival, and has been recently recognized as a potential target for cancer therapy. Ganetespib is a potent ATP competitive inhibitor of HSP90. Ganetespib downregulat...

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Bibliographic Details
Main Authors: Xinqi Wu, Melina E Marmarelis, F Stephen Hodi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572008?pdf=render

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