Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
The study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretation...
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doaj-c9eb1bf56f8f4f83a532544d13ce26c62020-11-25T03:56:18ZengMDPI AGJournal of Personalized Medicine2075-44262020-10-011019019010.3390/jpm10040190Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”Karani S. Vimaleswaran0Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading RG6 6DZ, UKThe study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretations of the study findings. The genotypes of the SNP are not in Hardy–Weinberg equilibrium (HWE) in both cases (<i>p</i> < 0.0001) and controls (<i>p</i> = 0.006), which is indicative of a technical error due to a problematic genotyping method. In addition, the genotype and allele frequencies reported in the study do not match with the frequencies listed in the SNP database for Asian Indians. While the study by Jha et al. reported ”T” allele as the minor allele, the dbSNP database reported ”A” as the minor allele. In summary, it can be concluded that the data presented in the study suffer from genotyping as well as data interpretation error and, hence, the findings should be considered by the reader with caution.https://www.mdpi.com/2075-4426/10/4/190omentin geneSNPrs2274907Hardy–Weinberg equilibriumARMS-PCR |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karani S. Vimaleswaran |
spellingShingle |
Karani S. Vimaleswaran Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” Journal of Personalized Medicine omentin gene SNP rs2274907 Hardy–Weinberg equilibrium ARMS-PCR |
author_facet |
Karani S. Vimaleswaran |
author_sort |
Karani S. Vimaleswaran |
title |
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” |
title_short |
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” |
title_full |
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” |
title_fullStr |
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” |
title_full_unstemmed |
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study” |
title_sort |
comment: “evaluation of the association of omentin 1 rs2274907 a>t and rs2274908 g>a gene polymorphisms with coronary artery disease in indian population: a case control study” |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2020-10-01 |
description |
The study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretations of the study findings. The genotypes of the SNP are not in Hardy–Weinberg equilibrium (HWE) in both cases (<i>p</i> < 0.0001) and controls (<i>p</i> = 0.006), which is indicative of a technical error due to a problematic genotyping method. In addition, the genotype and allele frequencies reported in the study do not match with the frequencies listed in the SNP database for Asian Indians. While the study by Jha et al. reported ”T” allele as the minor allele, the dbSNP database reported ”A” as the minor allele. In summary, it can be concluded that the data presented in the study suffer from genotyping as well as data interpretation error and, hence, the findings should be considered by the reader with caution. |
topic |
omentin gene SNP rs2274907 Hardy–Weinberg equilibrium ARMS-PCR |
url |
https://www.mdpi.com/2075-4426/10/4/190 |
work_keys_str_mv |
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