Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”

The study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretation...

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Main Author: Karani S. Vimaleswaran
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Journal of Personalized Medicine
Subjects:
SNP
Online Access:https://www.mdpi.com/2075-4426/10/4/190
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spelling doaj-c9eb1bf56f8f4f83a532544d13ce26c62020-11-25T03:56:18ZengMDPI AGJournal of Personalized Medicine2075-44262020-10-011019019010.3390/jpm10040190Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”Karani S. Vimaleswaran0Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading RG6 6DZ, UKThe study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretations of the study findings. The genotypes of the SNP are not in Hardy–Weinberg equilibrium (HWE) in both cases (<i>p</i> < 0.0001) and controls (<i>p</i> = 0.006), which is indicative of a technical error due to a problematic genotyping method. In addition, the genotype and allele frequencies reported in the study do not match with the frequencies listed in the SNP database for Asian Indians. While the study by Jha et al. reported ”T” allele as the minor allele, the dbSNP database reported ”A” as the minor allele. In summary, it can be concluded that the data presented in the study suffer from genotyping as well as data interpretation error and, hence, the findings should be considered by the reader with caution.https://www.mdpi.com/2075-4426/10/4/190omentin geneSNPrs2274907Hardy–Weinberg equilibriumARMS-PCR
collection DOAJ
language English
format Article
sources DOAJ
author Karani S. Vimaleswaran
spellingShingle Karani S. Vimaleswaran
Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
Journal of Personalized Medicine
omentin gene
SNP
rs2274907
Hardy–Weinberg equilibrium
ARMS-PCR
author_facet Karani S. Vimaleswaran
author_sort Karani S. Vimaleswaran
title Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
title_short Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
title_full Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
title_fullStr Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
title_full_unstemmed Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”
title_sort comment: “evaluation of the association of omentin 1 rs2274907 a>t and rs2274908 g>a gene polymorphisms with coronary artery disease in indian population: a case control study”
publisher MDPI AG
series Journal of Personalized Medicine
issn 2075-4426
publishDate 2020-10-01
description The study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretations of the study findings. The genotypes of the SNP are not in Hardy–Weinberg equilibrium (HWE) in both cases (<i>p</i> < 0.0001) and controls (<i>p</i> = 0.006), which is indicative of a technical error due to a problematic genotyping method. In addition, the genotype and allele frequencies reported in the study do not match with the frequencies listed in the SNP database for Asian Indians. While the study by Jha et al. reported ”T” allele as the minor allele, the dbSNP database reported ”A” as the minor allele. In summary, it can be concluded that the data presented in the study suffer from genotyping as well as data interpretation error and, hence, the findings should be considered by the reader with caution.
topic omentin gene
SNP
rs2274907
Hardy–Weinberg equilibrium
ARMS-PCR
url https://www.mdpi.com/2075-4426/10/4/190
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