Closed-Loop Characterization of Neuronal Activation Using Electrical Stimulation and Optical Imaging

Closed-Loop Characterization of Neuronal Activation Using Electrical Stimulation and Optical Imaging

We have developed a closed-loop, high-throughput system that applies electrical stimulation and optical recording to facilitate the rapid characterization of extracellular, stimulus-evoked neuronal activity. In our system, a microelectrode array delivers current pulses to a dissociated neuronal cult...

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Bibliographic Details
Main Authors: Michelle L. Kuykendal, Gareth S. Guvanasen, Steve M. Potter, Martha A. Grover, Stephen P. DeWeerth
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Processes
Subjects:
extracellular electrical stimulation
closed-loop
strength-duration
micro-electrode array (MEA)
dissociated culture
activation curve
optical recording
Online Access:http://www.mdpi.com/2227-9717/5/2/30

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