Carbohydrate-to-carbohydrate interactions between α2,3-linked sialic acids on α2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells

Carbohydrate-to-carbohydrate interactions between α2,3-linked sialic acids on α2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells

Complex interplays among proteins, lipids and carbohydrates can alter the phenotype and are suggested to have a crucial role in tumour metastasis. Our previous studies indicated that a complex of the GSLs (glycosphingolipids), AsGM1 (asialo-GM1), which lacks α2,3-linked sialic acid, and α2β1 integr...

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Bibliographic Details
Main Authors: Séverine Van Slambrouck, Sophie Groux‑Degroote, Marie‑Ange Krzewinski‑Recchi, Aurélie Cazet, Philippe Delannoy, Wim F. A. Steelant
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-09-01
Series:Bioscience Reports
Subjects:
bone metastasis
carbohydrate–carbohydrate interaction
collagen type I
glycosphingolipid
integrin
sialylation
Online Access:http://www.bioscirep.org/bsr/034/e138/bsr034e138.htm

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