A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms

A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms

Depressive symptoms could be considered a mutual manifestation of major depressive disorder and schizophrenia. Rs3758391 is a functional locus of Sirtuin (SIRT1) involving depression etiology. In this study, we hypothesized that the SIRT1 SNP rs3758391 might be a hazard for schizophrenia pathogenesi...

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Bibliographic Details
Main Authors: Dandan Wang, Wei Tang, Junxiong Zhao, Weixing Fan, Yi Zhang, Chen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
schizophrenia
depression
SIRT1
CDSS
association
polymorphism
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00832/full

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