Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database

Abstract Background The aim of this study was to determine the prevalence of cardiovascular disease in persons with type 2 diabetes mellitus (T2D) in Germany. Methods A claims database with an age- and sex-stratified sample of nearly 4 million individuals insured within the German statutory health s...

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Main Authors: Maximilian Gabler, Silke Geier, Lukas Mayerhoff, Wolfgang Rathmann
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Public Health
Subjects:
Online Access:https://doi.org/10.1186/s12889-021-10381-z
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spelling doaj-c9bbbd2043f64987a843750c879708f82021-02-14T12:03:58ZengBMCBMC Public Health1471-24582021-02-012111910.1186/s12889-021-10381-zCardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance databaseMaximilian Gabler0Silke Geier1Lukas Mayerhoff2Wolfgang Rathmann3Boehringer IngelheimBoehringer IngelheimFormer employee of Elsevier Health AnalyticsInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine UniversityAbstract Background The aim of this study was to determine the prevalence of cardiovascular disease in persons with type 2 diabetes mellitus (T2D) in Germany. Methods A claims database with an age- and sex-stratified sample of nearly 4 million individuals insured within the German statutory health system was used. All patients aged ≥18 years with T2D documented between 1 January 2015 and 31 December 2015 and complete retrospective documentation of ≥5 years (continuous enrollment in the German statutory health system) before 2015 were selected based on a validated algorithm. Cardiovascular disease (CVD) events were identified based on ICD-10 and OPS codes according to a previous clinical study (EMPA-REG OUTCOME trial). Results The prevalence of T2D in Germany in 2015 was 9.9% (n = 324,708). Using a narrow definition of CVD, the 6-year observation period prevalence of CVD was estimated as 46.7% [95% CI: 46.52%;46.86%]. Applying a wider CVD definition, the proportion of T2D patients who showed a history of CVD was 57.1% [95% CI: 56.9%;57.24%]. The prevalence of CVD in patients with T2D ranged from 36.3 to 57.1%, depending on the observation period and definition of CVD. Conclusions The results underline the need for a population-based registration of cardiovascular complications in T2D.https://doi.org/10.1186/s12889-021-10381-zSecondary data analysisEpidemiological studyPrevalence figuresType 2 diabetes mellitusCardiovascular disease
collection DOAJ
language English
format Article
sources DOAJ
author Maximilian Gabler
Silke Geier
Lukas Mayerhoff
Wolfgang Rathmann
spellingShingle Maximilian Gabler
Silke Geier
Lukas Mayerhoff
Wolfgang Rathmann
Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
BMC Public Health
Secondary data analysis
Epidemiological study
Prevalence figures
Type 2 diabetes mellitus
Cardiovascular disease
author_facet Maximilian Gabler
Silke Geier
Lukas Mayerhoff
Wolfgang Rathmann
author_sort Maximilian Gabler
title Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
title_short Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
title_full Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
title_fullStr Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
title_full_unstemmed Cardiovascular disease prevalence in type 2 diabetes – an analysis of a large German statutory health insurance database
title_sort cardiovascular disease prevalence in type 2 diabetes – an analysis of a large german statutory health insurance database
publisher BMC
series BMC Public Health
issn 1471-2458
publishDate 2021-02-01
description Abstract Background The aim of this study was to determine the prevalence of cardiovascular disease in persons with type 2 diabetes mellitus (T2D) in Germany. Methods A claims database with an age- and sex-stratified sample of nearly 4 million individuals insured within the German statutory health system was used. All patients aged ≥18 years with T2D documented between 1 January 2015 and 31 December 2015 and complete retrospective documentation of ≥5 years (continuous enrollment in the German statutory health system) before 2015 were selected based on a validated algorithm. Cardiovascular disease (CVD) events were identified based on ICD-10 and OPS codes according to a previous clinical study (EMPA-REG OUTCOME trial). Results The prevalence of T2D in Germany in 2015 was 9.9% (n = 324,708). Using a narrow definition of CVD, the 6-year observation period prevalence of CVD was estimated as 46.7% [95% CI: 46.52%;46.86%]. Applying a wider CVD definition, the proportion of T2D patients who showed a history of CVD was 57.1% [95% CI: 56.9%;57.24%]. The prevalence of CVD in patients with T2D ranged from 36.3 to 57.1%, depending on the observation period and definition of CVD. Conclusions The results underline the need for a population-based registration of cardiovascular complications in T2D.
topic Secondary data analysis
Epidemiological study
Prevalence figures
Type 2 diabetes mellitus
Cardiovascular disease
url https://doi.org/10.1186/s12889-021-10381-z
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