Complement, a Therapeutic Target in Diabetic Kidney Disease

Complement, a Therapeutic Target in Diabetic Kidney Disease

Currently available treatments of diabetic kidney disease (DKD) remain limited despite improved understanding of DKD pathophysiology. The complement system is a central part of innate immunity, but its dysregulated activation is detrimental and results in systemic diseases with overt inflammation. G...

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Bibliographic Details
Main Authors: Kelly Budge, Sergio Dellepiane, Samuel Mon-Wei Yu, Paolo Cravedi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Medicine
Subjects:
diabetes
diabetic kidney disease
C3a
complement
glomerulosclerosis
MAC
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.599236/full

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