Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins
One week after intranigral injection of thrombin resulted in a dose-dependent loss of dopaminergic neurons (20–78%) in the rat substantia nigra (SN), as evidenced by tyrosine hydroxylase (TH) immunohistochemistry. This cell death was accompanied by localization of terminal deoxynucleotidyl transfera...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2003-11-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103000858 |