Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader...

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Main Authors: Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M Lemon, Daisuke Yamane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009220
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spelling doaj-c99de97c15904b48a8e94d01b7b7f3b42021-04-29T04:30:48ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742021-01-01171e100922010.1371/journal.ppat.1009220Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.Hui FengYi-Bing ZhangJian-Fang GuiStanley M LemonDaisuke YamaneThe eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.https://doi.org/10.1371/journal.ppat.1009220
collection DOAJ
language English
format Article
sources DOAJ
author Hui Feng
Yi-Bing Zhang
Jian-Fang Gui
Stanley M Lemon
Daisuke Yamane
spellingShingle Hui Feng
Yi-Bing Zhang
Jian-Fang Gui
Stanley M Lemon
Daisuke Yamane
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
PLoS Pathogens
author_facet Hui Feng
Yi-Bing Zhang
Jian-Fang Gui
Stanley M Lemon
Daisuke Yamane
author_sort Hui Feng
title Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
title_short Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
title_full Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
title_fullStr Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
title_full_unstemmed Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.
title_sort interferon regulatory factor 1 (irf1) and anti-pathogen innate immune responses.
publisher Public Library of Science (PLoS)
series PLoS Pathogens
issn 1553-7366
1553-7374
publishDate 2021-01-01
description The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.
url https://doi.org/10.1371/journal.ppat.1009220
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