A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination

A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination

Abstract Background As annual influenza vaccination is recommended for all U.S. persons aged 6 months or older, it is unethical to conduct randomized clinical trials to estimate influenza vaccine effectiveness (VE). Observational studies are being increasingly used to estimate VE. We developed a pro...

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Bibliographic Details
Main Authors: Meng Shi, Qian An, Kylie E. C. Ainslie, Michael Haber, Walter A. Orenstein
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Infectious Diseases
Subjects:
Case-control study
Test-negative study
Probability model
Symptomatic influenza
Medically-attended influenza
Online Access:http://link.springer.com/article/10.1186/s12879-017-2838-2

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