An Integrative Systems Biology Approach Identifies Molecular Signatures Associated with Gallbladder Cancer Pathogenesis

An Integrative Systems Biology Approach Identifies Molecular Signatures Associated with Gallbladder Cancer Pathogenesis

Gallbladder cancer (GBC) has a lower incidence rate among the population relative to other cancer types but is a major contributor to the total number of biliary tract system cancer cases. GBC is distinguished from other malignancies by its high mortality, marked geographical variation and poor prog...

Full description

Bibliographic Details
Main Authors:	Nabanita Roy, Mrinmoy Kshattry, Susmita Mandal, Mohit Kumar Jolly, Dhruba Kumar Bhattacharyya, Pankaj Barah
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Journal of Clinical Medicine
Subjects:	gallbladder cancer transcriptomics differentially expressed genes co-expression network transcription factors epithelial-mesenchymal-transition
Online Access:	https://www.mdpi.com/2077-0383/10/16/3520

Similar Items

Research advances in the pathogenesis and surgical treatment of gallbladder carcinoma
by: ZHANG Fubo
Published: (2018-05-01)

Expression and clinicopathological correlation of Ki-67 in gallbladder carcinoma
by: Amit Gupta, et al.
Published: (2021-01-01)

Investigating epithelial‐mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling
by: Federico Bocci, et al.
Published: (2021-06-01)

Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum
by: Priyanka Chakraborty, et al.
Published: (2021-04-01)

Expression and Clinical Implications of Cysteine Cathepsins in Gallbladder Carcinoma
by: Siddharth Mehra, et al.
Published: (2019-11-01)

Gastrulation EMT Is Independent of P-Cadherin Downregulation
by: Moly, Pricila K., et al.
Published: (2016)

Intrahepatic Gallbladder
by: Sherif Monib, et al.
Published: (2019-05-01)

A retrospecti̇ve evaluation of the epitelial lesions / neoplasms of the gallbladder in Usak city and determination of the visual frequency
by: Sirin Kucuk, et al.
Published: (2020-03-01)

Type I EMT Inducer Eomesodermin has a Significant expression in Breast Cancer
by: Mina Matinzadeh, et al.
Published: (2016-11-01)

MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer
by: Min He, et al.
Published: (2017-08-01)

Agenesis of the gallbladder and cystic duct
by: Jaques Waisberg, et al.

A Novel Gemcitabine-Resistant Gallbladder Cancer Model Provides Insights into Molecular Changes Occurring during Acquired Resistance
by: Bizama, C., et al.
Published: (2023)

RNAseq Reveals Complex Response of Campylobacter jejuni to Ovine Bile and In vivo Gallbladder Environment
by: Amanda J. Kreuder, et al.
Published: (2017-05-01)

Pathogenesis of gallbladder adenomyomatosis and its relationship with early-stage gallbladder carcinoma: an overview
by: Liwei Pang, et al.
Published: (2018-05-01)

Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma
by: Changhong Yang, et al.
Published: (2021-02-01)

MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine
by: Liu Wensheng, et al.
Published: (2019-09-01)

Identification of Gene Signatures and Expression Patterns During Epithelial-to-Mesenchymal Transition From Single-Cell Expression Atlas
by: Xiangtian Yu, et al.
Published: (2021-01-01)

Septate gallbladder in the laparoscopic era
by: Patel Nitin, et al.
Published: (2008-01-01)

Recent Updates on Diagnosis, Treatment, and Follow-up of Gallbladder Polyps
by: Sung Ill Jang, et al.
Published: (2020-09-01)

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology
by: Satwik Pasani, et al.
Published: (2021-12-01)

Cavernous Hemangioma of the Gallbladder Masquerading as a Carcinoma
by: Naotake Funamizu, et al.
Published: (2019-04-01)

Ischemic gallbladder perforation
by: T Vancauwenberghe, et al.
Published: (2011-03-01)

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum
by: Priyanka Chakraborty, et al.
Published: (2021-01-01)

Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity
by: Satyendra Chandra Tripathi, et al.
Published: (2021-01-01)

Concomitant Expression of Prolactin Receptor and TGFβ Receptors in Breast Cancer: Association with Less Aggressive Phenotype and Favorable Patient Outcome
by: Ibrahim Y. Hachim, et al.
Published: (2019-04-01)

Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer
by: Takuo Ogihara, et al.
Published: (2020-11-01)

Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer
by: Dinesh Singh Tekcham, et al.
Published: (2016-01-01)

Correlative Imaging in Gallbladder Carcinoma
by: Dr I. Willekens, et al.
Published: (2014-09-01)

Carcinosarcoma Gallbladder: A Rare Variety of Gallbladder Malignancy
by: Koustav Jana, et al.
Published: (2018-04-01)

Current management strategies in gallbladder cancers
by: Vikas Ostwal, et al.
Published: (2018-01-01)

Evaluation of Patients Diagnosed with Incidental Gallbladder Cancers After Cholecystectomy
by: Oğuz Çatal, et al.
Published: (2019-06-01)

Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial–Mesenchymal Plasticity
by: Barbora Kvokačková, et al.
Published: (2021-05-01)

Antegrade method of laparoscopic cholecystectomy for left sided gallbladder
by: Sang Kyun Mok, et al.
Published: (2020-03-01)

Left-sided gallbladder: An incidental finding on laparoscopic cholecystectomy
by: Amin Makni, et al.
Published: (2012-04-01)

Surgical treatment of gallbladder polypoid lesions
by: Pejić Miljko A., et al.
Published: (2003-01-01)

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor
by: Patricia García, et al.
Published: (2020-04-01)

Gallbladder disease in patients with primary sclerosing cholangitis** Said K, Glaumann H, Bergquist A. Gallbladder disease in patients with primary sclerosing cholangitis. J Hepatol 2008; 48: 598-605.
by: Genaro Vázquez-Elizondo, et al.
Published: (2008-04-01)

Metastatic gallbladder carcinoma presenting as an ovarian mass
by: Nidhin Rehman, et al.
Published: (2021-04-01)

Changes in plasma bile acids are associated with gallbladder stones and polyps
by: Linshi Wu, et al.
Published: (2020-10-01)

Spontaneous transhepatic rupture of the gallbladder with massive hemoperitoneum.
by: B Coulier, et al.
Published: (2012-03-01)