Computational Investigation of the pH Dependence of Stability of Melanosome Proteins: Implication for Melanosome formation and Disease

Computational Investigation of the pH Dependence of Stability of Melanosome Proteins: Implication for Melanosome formation and Disease

Intravesicular pH plays a crucial role in melanosome maturation and function. Melanosomal pH changes during maturation from very acidic in the early stages to neutral in late stages. Neutral pH is critical for providing optimal conditions for the rate-limiting, pH-sensitive melanin-synthesizing enzy...

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Bibliographic Details
Main Authors: Mahesh Koirala, H. B. Mihiri Shashikala, Jacob Jeffries, Bohua Wu, Stacie K. Loftus, Jonathan H. Zippin, Emil Alexov
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pH dependence
proton transport
pH regulation
stability
Online Access:https://www.mdpi.com/1422-0067/22/15/8273

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