Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: Case Report

• Main Authors: Allison Robin W, Lukaszewska Janina, Stepkowska Julita
• Format: Article
• Language: English
• Published: BMC 2011-03-01
• Series: Acta Veterinaria Scandinavica
• Online Access: http://www.actavetscand.com/content/53/1/14

<p>Abstract</p> <p>A 13 year old Danish/Swedish Farmdog from Denmark was evaluated in a veterinary clinic in Warsaw, Poland for evaluation of an orthopedic problem. Radiographs revealed spondylosis and degenerative vertebral disease, which responded to treatment with anti-inflammatory medications. A predominance of hyposegmented neutrophils and eosinophils containing condensed chromatin and normal cytoplasm were identified on a routine CBC. Follow-up blood film evaluations over the course of 12 months confirmed that the hyposegmented granulocytes persisted. The majority of neutrophils contained Grade 2 nuclei (slightly indented), and the mean nuclear score varied from 1.9 to 2.3. Pelger-Huët anomaly (PHA), presumably congenital, was diagnosed based on persistent hyposegmented granulocytes in the absence of an underlying cause for acquired PHA; genetically related dogs were unavailable for testing to confirm vertical transmission. To the authors' knowledge this is the first report of PHA in a Danish/Swedish Farmdog.</p>