The dynamic side of the Warburg effect: glycolytic intermediate storage as buffer for fluctuating glucose and O2 supply in tumor cells [version 2; referees: 2 approved]
Background: Tumor cells often show altered metabolism which supports uncontrolled proliferation. A classic example is the Warburg effect: high glucose uptake and lactate production despite sufficient oxygen supply. Remarkably, tumor cells can transiently take up glucose even an order of magnitude fa...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-12-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1177/v2 |