Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation.

Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation.

SINEUPs are antisense long noncoding RNAs, in which an embedded SINE B2 element UP-regulates translation of partially overlapping target sense mRNAs. SINEUPs contain two functional domains. First, the binding domain (BD) is located in the region antisense to the target, providing specific targeting...

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Bibliographic Details
Main Authors: Hazuki Takahashi, Ana Kozhuharova, Harshita Sharma, Masakazu Hirose, Takako Ohyama, Francesca Fasolo, Toshio Yamazaki, Diego Cotella, Claudio Santoro, Silvia Zucchelli, Stefano Gustincich, Piero Carninci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5802440?pdf=render

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