| Summary: | To monitor variations of blood samples effectively, it is required to quantify static and dynamic properties simultaneously. With previous approaches, the viscosity and elasticity of blood samples are obtained for static and transient flows with two syringe pumps. In this study, simultaneous measurement of pressure and equivalent compliance is suggested by analyzing the velocity fields of blood flows, where a blood sample is delivered in a periodic on-off fashion with a single syringe pump. The microfluidic device is composed of a main channel (mc) for quantifying the equivalent compliance and a pressure channel (pc) for measuring the blood pressure. Based on the mathematical relation, blood pressure at junction (<i>P<sub>x</sub></i>) is expressed as <i>P<sub>x</sub></i> = <i>k</i><i>β</i>. Here, <i>β</i> is calculated by integrating the averaged velocity in the pressure channel (<i><U<sub>pc</sub>></i>). The equivalent compliance (<i>C<sub>eq</sub></i>) is then quantified as <i>C<sub>eq</sub></i> = <i>λ<sub>off</sub></i> · <i>Q</i><sub>0</sub>/<i>P<sub>x</sub></i> with a discrete fluidic model. The time constant (<i>λ<sub>off</sub></i> ) is obtained from the transient behavior of the averaged blood velocity in the main channel (<<i>U<sub>mc</sub></i>>). According to results, <i>P<sub>x</sub></i> and <i>C<sub>eq</sub></i> varied considerably with respect to the hematocrit and flow rate. The present method (i.e., blood pressure, compliance) shows a strong correlation with the previous method (i.e., blood viscosity, elasticity). In conclusion, the present method can be considered as a potential tool for monitoring the mechanical properties of blood samples supplied periodically from a single syringe pump.
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