Nanoparticle Activation Methods in Cancer Treatment

In this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-targe...

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Main Authors:	Benjamin D White, Chengchen Duan, Helen E Townley
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Biomolecules
Subjects:	cancer tumour activation nanosystems temporal spatial extrinsic intrinsic
Online Access:	https://www.mdpi.com/2218-273X/9/5/202

id	doaj-c96b6d2b52ce4fd2afa3601472c27f26
record_format	Article
spelling	doaj-c96b6d2b52ce4fd2afa3601472c27f262020-11-24T21:40:43ZengMDPI AGBiomolecules2218-273X2019-05-019520210.3390/biom9050202biom9050202Nanoparticle Activation Methods in Cancer TreatmentBenjamin D White0Chengchen Duan1Helen E Townley2Department of Engineering Science, Oxford University, Parks Road, Oxford OX1 3PJ, UKNuffield Department of Women’s and Reproductive Health, Oxford University John Radcliffe Hospital, Headington, Oxford OX3 9DU, UKDepartment of Engineering Science, Oxford University, Parks Road, Oxford OX1 3PJ, UKIn this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-target effects. This has led to the development of smart nanosystems which can effect specific regional and temporal activation. In this review, we will discuss the different methodologies which have been designed to permit activation at the tumour site. These can be divided into mechanisms which take advantage of the differences between healthy cells and cancer cells to trigger activation, and those which activate by a mechanism extrinsic to the cell or tumour environment.https://www.mdpi.com/2218-273X/9/5/202cancertumouractivationnanosystemstemporalspatialextrinsicintrinsic
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Benjamin D White Chengchen Duan Helen E Townley
spellingShingle	Benjamin D White Chengchen Duan Helen E Townley Nanoparticle Activation Methods in Cancer Treatment Biomolecules cancer tumour activation nanosystems temporal spatial extrinsic intrinsic
author_facet	Benjamin D White Chengchen Duan Helen E Townley
author_sort	Benjamin D White
title	Nanoparticle Activation Methods in Cancer Treatment
title_short	Nanoparticle Activation Methods in Cancer Treatment
title_full	Nanoparticle Activation Methods in Cancer Treatment
title_fullStr	Nanoparticle Activation Methods in Cancer Treatment
title_full_unstemmed	Nanoparticle Activation Methods in Cancer Treatment
title_sort	nanoparticle activation methods in cancer treatment
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2019-05-01
description	In this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-target effects. This has led to the development of smart nanosystems which can effect specific regional and temporal activation. In this review, we will discuss the different methodologies which have been designed to permit activation at the tumour site. These can be divided into mechanisms which take advantage of the differences between healthy cells and cancer cells to trigger activation, and those which activate by a mechanism extrinsic to the cell or tumour environment.
topic	cancer tumour activation nanosystems temporal spatial extrinsic intrinsic
url	https://www.mdpi.com/2218-273X/9/5/202
work_keys_str_mv	AT benjamindwhite nanoparticleactivationmethodsincancertreatment AT chengchenduan nanoparticleactivationmethodsincancertreatment AT helenetownley nanoparticleactivationmethodsincancertreatment
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Nanoparticle Activation Methods in Cancer Treatment

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