Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essential Plasmodium protease and a highly promising ant...

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Main Authors: Luca Gambini, Luca Rizzi, Alessandro Pedretti, Orazio Taglialatela-Scafati, Mario Carucci, Andrea Pancotti, Corinna Galli, Martin Read, Emanuele Giurisato, Sergio Romeo, Ilaria Russo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4643876?pdf=render

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