The Influence of Milling on the Dissolution Performance of Simvastatin

The Influence of Milling on the Dissolution Performance of Simvastatin

Particle size reduction is a simple means to enhance the dissolution rate of poorly water soluble BCS-class II and IV drugs. However, the major drawback of this process is the possible introduction of process induced disorder. Drugs with different molecular arrangements may exhibit altered propertie...

Full description

Bibliographic Details
Main Authors: Thomas Rades, Clare J. Strachan, Ulrike Zimper, Jaakko Aaltonen, Keith C. Gordon, Karen Krauel-Goellner
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Pharmaceutics
Subjects:
dissolution rate
ball milling
process induced disorder
response surface modeling
simvastatin
Online Access:http://www.mdpi.com/1999-4923/2/4/419/

Similar Items

Similar Items