Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease

Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease

Over the last few decades, there has been a significant increase in epidemiological studies suggesting that type 2 diabetes (T2DM) is linked to a higher risk of Alzheimer's disease (AD). However, how T2DM affects AD pathology, such as tau hyperphosphorylation, is not well understood. In this st...

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Bibliographic Details
Main Authors: Maud Gratuze, Noura B. El Khoury, Andréanne Turgeon, Carl Julien, François Marcouiller, Françoise Morin, Robert A. Whittington, André Marette, Frédéric Calon, Emmanuel Planel
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Diabetes mellitus
ob/ob mice
Tau hyperphosphorylation, hippocampus
Kinase
Phosphatase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302443

Internet

http://www.sciencedirect.com/science/article/pii/S0969996116302443

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