T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death

T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death

T315, an integrin-linked kinase (ILK) inhibitor, has been shown to suppress the proliferation of breast cancer, stomach cancer and chronic lymphocytic leukemia cells. Here we demonstrate that T315 decreases cell viability of acute myeloid leukemia (AML) cell lines (HL-60 and THP-1) and primary leuke...

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Bibliographic Details
Main Authors: Chang-Fang Chiu, Jing-Ru Weng, Appaso Jadhav, Chia-Yung Wu, Aaron M. Sargeant, Li-Yuan Bai
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
T315
acute myeloid leukemia
apoptosis
autophagy
autophagic cell death
Online Access:http://www.mdpi.com/1422-0067/17/8/1337

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