ERCC1 and ERCC2 haplotype modulates induced BPDE-DNA adducts in primary cultured lymphocytes.

ERCC1 and ERCC2 haplotype modulates induced BPDE-DNA adducts in primary cultured lymphocytes.

BACKGROUND: Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/XPD exert an indispensable role. Genetic vari...

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Bibliographic Details
Main Authors: Xiaobo Lu, Yanhua Liu, Tao Yu, Sha Xiao, Xiaoyan Bao, Liang Pan, Guolian Zhu, Yuan Cai, Qiufang Liu, Cuihong Jin, Jinghua Yang, Shengwen Wu, Li An, Tahar van der Straaten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3617188?pdf=render

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