| Summary: | We report a rare case of a benign giant mediastinal lipoblastoma in an older Pediatric patient (12-year-old male) presenting with mild cough, fatigue, and shortness of breath on exertion. Of note, the patient, although complained of cough with supine positioning, was able to lie flat. Initial chest x-ray revealed near opacification of the left hemithorax, with contralateral mediastinal shift. The patient was transferred to a tertiary care children's hospital and underwent computed tomography (CT) imaging. CT was most compatible with a teratoma; however, operative management and histological analysis confirmed a diagnosis of lipoblastoma. Lipoblastomas are a rare, benign, rapidly growing tumor most often found in the extremities, and almost exclusively affecting children under the age of 5 years. We discuss our case of an uncommon tumor in an older patient, in a rare location. We review the literature of all previously reported mediastinal lipoblastomas in the Pediatric population. Keywords: Giant mediastinal lipoblastoma, Pediatric surgery, General surgery
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