Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Ch...

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Main Authors: Basel MT, Balivada S, Wang H, Shrestha TB, Seo GM, Pyle M, Abayaweera G, Dani R, Koper OB, Tamura M, Chikan V, Bossmann SH, Troyer DL
Format: Article
Language:English
Published: Dove Medical Press 2012-01-01
Series:International Journal of Nanomedicine
Online Access:http://www.dovepress.com/cell-delivered-magnetic-nanoparticles-caused-hyperthermia-mediated-inc-a9085
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spelling doaj-c92b841d03d846d28b922735a7e5ddfd2020-11-25T02:17:15ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132012-01-012012default297306Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer modelBasel MTBalivada SWang HShrestha TBSeo GMPyle MAbayaweera GDani RKoper OBTamura MChikan VBossmann SHTroyer DLMatthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticleshttp://www.dovepress.com/cell-delivered-magnetic-nanoparticles-caused-hyperthermia-mediated-inc-a9085
collection DOAJ
language English
format Article
sources DOAJ
author Basel MT
Balivada S
Wang H
Shrestha TB
Seo GM
Pyle M
Abayaweera G
Dani R
Koper OB
Tamura M
Chikan V
Bossmann SH
Troyer DL
spellingShingle Basel MT
Balivada S
Wang H
Shrestha TB
Seo GM
Pyle M
Abayaweera G
Dani R
Koper OB
Tamura M
Chikan V
Bossmann SH
Troyer DL
Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
International Journal of Nanomedicine
author_facet Basel MT
Balivada S
Wang H
Shrestha TB
Seo GM
Pyle M
Abayaweera G
Dani R
Koper OB
Tamura M
Chikan V
Bossmann SH
Troyer DL
author_sort Basel MT
title Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
title_short Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
title_full Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
title_fullStr Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
title_full_unstemmed Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
title_sort cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
publisher Dove Medical Press
series International Journal of Nanomedicine
issn 1176-9114
1178-2013
publishDate 2012-01-01
description Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticles
url http://www.dovepress.com/cell-delivered-magnetic-nanoparticles-caused-hyperthermia-mediated-inc-a9085
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