Systemic inhibition of NF-kappaB activation protects from silicosis.

Systemic inhibition of NF-kappaB activation protects from silicosis.

Silicosis is a complex lung disease for which no successful treatment is available and therefore lung transplantation is a potential alternative. Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathogenesis of silicosis. TNFalpha signaling is mediated by the transcription factor,...

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Main Authors: Michelangelo Di Giuseppe, Federica Gambelli, Gary W Hoyle, Giuseppe Lungarella, Sean M Studer, Thomas Richards, Sam Yousem, Ken McCurry, James Dauber, Naftali Kaminski, George Leikauf, Luis A Ortiz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2682759?pdf=render

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