Potent Skin Cancer Chemopreventing Activity of Some Novel

• Main Authors: Sherief Khalifa, Shabana Khan, Harukuni Tokuda, Takao Konoshima, Jordan K. Zjawiony, Hesham Fahmy
• Format: Article
• Language: English
• Published: MDPI AG 2006-03-01
• Series: Marine Drugs
• Subjects: Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum
• Online Access: http://www.mdpi.com/1660-3397/4/2/28/

Abstract: In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well asthe multiplicity of skin tumors per mouse compared to untreated controls.Semi-synthetic Cembranoids from Marine Sources