Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD

Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD

Since the discovery of the C9orf72 repeat expansion mutation as causative for chromosome 9-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in 2011, a multitude of cellular pathways have been implicated. However, evidence has also been accumulating for a key mechanism of...

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Bibliographic Details
Main Authors: Daniel A. Solomon, Rebekah Smikle, Matthew J. Reid, Sarah Mizielinska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
phase separation
C9orf72
membraneless organelles
TDP-43
therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.664151/full

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