Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered Testosterone Undecanoate

Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered Testosterone Undecanoate

The bioavailability of orally administered drugs could be impacted by intestinal and hepatic first-pass metabolism. Testosterone undecanoate (TU), an orally administered ester prodrug of testosterone, is significantly subjected to first-pass metabolism. However, the individual contribution of intest...

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Bibliographic Details
Main Authors: Atheer Zgair, Yousaf Dawood, Suhaib M. Ibrahem, Hyun-moon Back, Leonid Kagan, Pavel Gershkovich, Jong Bong Lee
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Applied Sciences
Subjects:
testosterone undecanoate
first-pass metabolism
bioavailability
human liver microsomes
Caco-2 cells
Online Access:https://www.mdpi.com/2076-3417/10/20/7283

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